Table 1.
Baseline Characteristics of 98,451 participants from PLCO Cancer Screening Trial by fCDAI Quartiles.
| Title 1 | 1 (n = 24,613) |
2 (n = 24,613) |
3 (n = 24,613) |
4 (n = 24,612) |
Overall (n = 98,451) |
p-Value |
|---|---|---|---|---|---|---|
| Age | ||||||
| Mean (SD) | 62.7 (5.34) | 62.5 (5.28) | 62.4 (5.27) | 62.0 (5.20) | 62.4 (5.28) | <0.001 |
| Median [Min, Max] | 62.0 [53.0, 75.0] | 62.0 [54.0, 74.0] | 62.0 [54.0, 78.0] | 61.0 [54.0, 75.0] | 62.0 [53.0, 78.0] | |
| Sex | ||||||
| Male | 8861 (36.0%) | 10,742 (43.6%) | 12,585 (51.1%) | 15,474 (62.9%) | 47,662 (48.4%) | <0.001 |
| Female | 15,752 (64.0%) | 13,871 (56.4%) | 12,028 (48.9%) | 9138 (37.1%) | 50,789 (51.6%) | |
| Race | ||||||
| White, Non-Hispanic | 21,868 (88.8%) | 22,605 (91.8%) | 22,806 (92.7%) | 22,299 (90.6%) | 89,578 (91.0%) | <0.001 |
| Black, Non-Hispanic | 992 (4.0%) | 730 (3.0%) | 645 (2.6%) | 844 (3.4%) | 3211 (3.3%) | |
| Hispanic | 394 (1.6%) | 316 (1.3%) | 344 (1.4%) | 386 (1.6%) | 1440 (1.5%) | |
| Asian | 1182 (4.8%) | 817 (3.3%) | 664 (2.7%) | 874 (3.6%) | 3537 (3.6%) | |
| Pacific Islander | 111 (0.5%) | 103 (0.4%) | 102 (0.4%) | 139 (0.6%) | 455 (0.5%) | |
| American Indian | 58 (0.2%) | 31 (0.1%) | 45 (0.2%) | 62 (0.3%) | 196 (0.2%) | |
| Missing | 8 (0.0%) | 11 (0.0%) | 7 (0.0%) | 8 (0.0%) | 34 (0.0%) | |
| Study arm | ||||||
| Intervention | 12,422 (50.5%) | 12,468 (50.7%) | 12,722 (51.7%) | 12,795 (52.0%) | 50,407 (51.2%) | 0.00229 |
| Control | 12,191 (49.5%) | 12,145 (49.3%) | 11,891 (48.3%) | 11,817 (48.0%) | 48,044 (48.8%) | |
| Education | ||||||
| Less Than 8 Years | 177 (0.7%) | 115 (0.5%) | 138 (0.6%) | 167 (0.7%) | 597 (0.6%) | <0.001 |
| 8–11 Years | 1539 (6.3%) | 1307 (5.3%) | 1203 (4.9%) | 1216 (4.9%) | 5265 (5.3%) | |
| 12 Years or Completed High School | 6938 (28.2%) | 5883 (23.9%) | 5284 (21.5%) | 4815 (19.6%) | 22,920 (23.3%) | |
| Post High School Training Other than College | 3251 (13.2%) | 3204 (13.0%) | 3238 (13.2%) | 3036 (12.3%) | 12,729 (12.9%) | |
| Some College | 5515 (22.4%) | 5218 (21.2%) | 5213 (21.2%) | 5210 (21.2%) | 21,156 (21.5%) | |
| College Graduate | 3686 (15.0%) | 4440 (18.0%) | 4605 (18.7%) | 4607 (18.7%) | 17,338 (17.6%) | |
| Postgraduate | 3507 (14.2%) | 4446 (18.1%) | 4932 (20.0%) | 5561 (22.6%) | 18,446 (18.7%) | |
| BMI | ||||||
| 0–18.5 | 186 (0.8%) | 186 (0.8%) | 156 (0.6%) | 136 (0.6%) | 664 (0.7%) | <0.001 |
| 18.5–25 | 8780 (35.7%) | 8610 (35.0%) | 8338 (33.9%) | 7449 (30.3%) | 33,177 (33.7%) | |
| 25–30 | 10,041 (40.8%) | 10,373 (42.1%) | 10,595 (43.0%) | 10,940 (44.4%) | 41,949 (42.6%) | |
| 30+ | 5606 (22.8%) | 5444 (22.1%) | 5524 (22.4%) | 6087 (24.7%) | 22,661 (23.0%) | |
| Marital status | ||||||
| Married Or Living As Married | 18,461 (75.0%) | 19,464 (79.1%) | 19,755 (80.3%) | 19,575 (79.5%) | 77,255 (78.5%) | <0.001 |
| Widowed | 2545 (10.3%) | 2024 (8.2%) | 1812 (7.4%) | 1571 (6.4%) | 7952 (8.1%) | |
| Divorced | 2647 (10.8%) | 2199 (8.9%) | 2150 (8.7%) | 2385 (9.7%) | 9381 (9.5%) | |
| Separated | 196 (0.8%) | 162 (0.7%) | 172 (0.7%) | 228 (0.9%) | 758 (0.8%) | |
| Never Married | 764 (3.1%) | 764 (3.1%) | 724 (2.9%) | 853 (3.5%) | 3105 (3.2%) | |
| Family history of any cancer | ||||||
| No | 10,701 (43.5%) | 10,811 (43.9%) | 10,854 (44.1%) | 11,075 (45.0%) | 43,441 (44.1%) | 0.0158 |
| Yes, Immediate Family Member | 2665 (10.8%) | 2573 (10.5%) | 2556 (10.4%) | 2504 (10.2%) | 10,298 (10.5%) | |
| Possibly Relative or Cancer Type Not Clear | 632 (2.6%) | 559 (2.3%) | 581 (2.4%) | 591 (2.4%) | 2363 (2.4%) | |
| Smoking status | ||||||
| Never Smoked Cigarettes | 12,318 (50.0%) | 12,152 (49.4%) | 11,757 (47.8%) | 11,310 (46.0%) | 47,537 (48.3%) | <0.001 |
| Current Cigarette Smoker | 2579 (10.5%) | 2204 (9.0%) | 2135 (8.7%) | 2189 (8.9%) | 9107 (9.3%) | |
| Former Cigarette Smoker | 9716 (39.5%) | 10,257 (41.7%) | 10,721 (43.6%) | 11,113 (45.2%) | 41,807 (42.5%) | |
| Alcohol drinking status | ||||||
| Never | 3008 (12.2%) | 2593 (10.5%) | 2236 (9.1%) | 2103 (8.5%) | 9940 (10.1%) | <0.001 |
| Former | 3759 (15.3%) | 3494 (14.2%) | 3446 (14.0%) | 3570 (14.5%) | 14,269 (14.5%) | |
| Current | 17,001 (69.1%) | 17,838 (72.5%) | 18,323 (74.4%) | 18,308 (74.4%) | 71,470 (72.6%) | |
| Unknown | 845 (3.4%) | 688 (2.8%) | 608 (2.5%) | 631 (2.6%) | 2772 (2.8%) | |
| Total energy | ||||||
| Mean (SD) | 1050 (300) | 1480 (325) | 1850 (411) | 2570 (740) | 1740 (735) | <0.001 |
| Median [Min, Max] | 1030 [466, 4970] | 1450 [550, 5390] | 1810 [622, 5540] | 2450 [644, 5620] | 1610 [466, 5620] | |
| fCADI | ||||||
| Mean (SD) | −5.07 (1.23) | −2.07 (0.727) | 0.682 (0.928) | 6.46 (3.93) | −0.0000000675 (4.76) | <0.001 |
| Median [Min, Max] | −4.85 [−10.1, −3.34] | −2.08 [−3.34, −0.805] | 0.618 [−0.805, 2.43] | 5.29 [2.43, 42.0] | −0.805 [−10.1, 42.0] |