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. 2023 Feb 6;123(4):1552–1634. doi: 10.1021/acs.chemrev.2c00316

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© 2023 The Authors. Published by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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Acidic margin-guided brain tumor surgery in live rat models. (A) Preoperative MRI image of rat brain bearing C6 orthotopic allografts. The tumor is indicated by a white arrow. (B) In vivo chemical exchange saturation transfer (CEST)-MRI pH map of a rat brain model. (C) Illustration indicating the surgical location before the craniotomy. (D) Sequential white light images (left panel), intraoperatively collected Raman spectra (middle panel), and a pH topographic map (right panel) of the resection bed. Reproduced with permission from ref (494). Copyright 2020 Royal Society of Chemistry.