Table 8.
Effects of curcumin on zinc toxicity based on doses, experimental methods, and findings.
| Dose/Concentration | Name of Animal Model/Cell Lines | Route of Exposure | Duration of Exposure/Treatment | Results | Source |
|---|---|---|---|---|---|
| In Vivo | |||||
| 5.6 mg/kg b.w. ZnONP + 200 mg/kg CUR | Male albino rats | ZnONP-IP/CUR-oral gavage | ZnONP-28 days (started on day 7, three times per week)/CUR-28 days (pre-treatment) | ↑cerebellum structure, ↓oxidative stress markers, ↑inflammatory response, ↓COX-2, P53 |
[52] |
| 50 mg/kg ZnONP + 200 mg/kg CUR | Male Wistar rats | ZnONP, CUR-orally | ZnONP-14 days (started on day 7)/CUR-14 days (pre-treatment) | ↑body, kidney weight, ↓MDA in the renal tissue, ↑SOD, GPx, ↓histological changes, ↓apoptotic index |
[162] |
| 50 mg/kg nano-ZnO + 200 mg/kg CUR | Male Wistar rats | ZnO-gavage method/ CUR- oral gavage |
ZnO-21 days (started on day 7)/CUR-21 days (pre-treatment)2 | ↓lipid peroxidation, ↑SOD, GPx ↓ALT, AST, ALP, ↓histology changes, ↓apoptotic index of hepatocytes |
[163] |
Abbreviations: ↑ = increase; ↓ = decrease; CUR = curcumin; Zn = zinc; ZnO = zinc oxide; ZnONP = zinc oxide nanoparticles; IP = intraperitoneal injection; P53 = tumor protein P53; COX-2 = prostaglandin-endoperoxide synthase 2; MDA = malondialdehyde; SOD = superoxide dismutase; GPx = glutathione peroxidase; ALT = alanine aminotransferase; AST = aspartate aminotransferase; ALP = alkaline phosphatase.