Table 9.
Effects of curcumin on mercury toxicity based on doses, experimental methods, and findings.
| Dose/Concentration | Name of Animal Model/Cell Lines | Route of Exposure | Duration of Exposure/Treatment | Results | Source |
|---|---|---|---|---|---|
| In Vivo | |||||
| 12 µmol/kg b.w. HgCl2 + 80 mg/kg b.w. CUR | Male Wistar rats | HgCl2-IP/CUR-orally | HgCl2-ones(pre/post-treated groups)/CUR-3 days(post-treatment, pre-treatment) | ↓oxidative stress, ↓lipid peroxidation, ↑GSH, SOD GPx, CAT in the liver, kidney, brain, ↓serum biochemical changes, ↓Hg in tissues |
[168] |
| 5 mg/kg HgCl2 + 50 mg/kg b.w. CUR | Kunming male mice | HgCl2, CUR-IP | HgCl2-ones/CUR-24 h (pre-treatment) | ↓autophagic cell death, ↓Na overload, ↓Ca leak, ↑Nrf2 signaling pathway, ↑antioxidant defenses | [169] |
| 10 ppm HgCl2 + 150 or 300 ppm CUR | Pregnant Swiss-Webster strain mice | HgCl2, CUR-oral gavage | 15 days (co-administration) | ↓biochemical, behavioral disorders, ↑cognitive, anxiety behaviors |
[170] |
Abbreviations: ↑ = increase; ↓ = decrease; CUR = curcumin; Hg = mercury; IP = intraperitoneal injection; SOD = superoxide dismutase; GPx = glutathione peroxidase; GSH = glutathione; Nrf2 = nuclear factor erythroid 2–related factor 2; Ca = calcium; Na = sodium; HgCl2 = mercury (II) chloride.