Table 10.

Effects of curcumin on selenium toxicity based on doses, experimental methods, and findings.

Dose/Concentration	Name of Animal Model/Cell Lines	Route of Exposure	Duration of Exposure/Treatment	Results	Source
In Vivo
15 µM/kg b.w. Se + 75 mg/kg b.w. CUR	Wistar rats	Se-IP/CUR-orally	Se-ones(co/pre/post-treated groups)/CUR-ones (co-administration, post-treatment, pre-treatment)	↓liver cells damage, ↓architecture changes of glomeruli and tubules, ↓iNOS	[175]
15 µM/kg b.w. Se + 75 mg/kg b.w. CUR	Wistar rat pups	Se-IP/CUR-orally	Se-ones(co/pre/post-treated groups)/CUR-ones (co-administration, post-treatment, pre-treatment)	↓LPO, ↓SOD, GST, GPx, CAT, ↓GSH, vitamin C, vitamin E	[177]
In Vitro
100 μM Na2SeO3 + 100 μM or 200 μM CUR	Wistar Rat pups	Isolated lenses incubation in DMEM	62 h	↓oxidative stress, ↓cataract formation	[176]

Abbreviations: ↑ = increase; ↓ = decrease; CUR = curcumin; Se = selenium; IP = intraperitoneal injection; iNOS = inducible nitric oxide synthase; DMEM = Dulbecco’s modified eagle medium; SOD = superoxide dismutase; GPx = glutathione peroxidase; GST = glutathione S-transferases; GSH = glutathione; CAT = catalase; LPO = lipid peroxidation; Na₂SeO₃ = sodium selenite.