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. 2023 Jan 24;12(2):261. doi: 10.3390/antiox12020261

Figure 1.

Figure 1

Ferroptosis modulators affect α-Syn-induced toxicity. (A) Lifespan analysis. α-Syn mutants lived significantly less than control flies. (B) Lifespan analysis. FAC significantly enhanced α-Syn-induced toxicity while DEF significantly protected flies against α-Syn-dependent toxicity. (C) Lifespan analysis. Erastin significantly enhanced α-Syn-induced toxicity, while NAC significantly protected flies against α-Syn-dependent toxicity (Mantel–Cox log-rank test: **** and ** indicate p < 0.0001, and <0.01). N: 135 TH/+, 54 TH > α-Syn, 80 FAC, 72 DEF, 20 Erastin, and 64 NAC.