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. 2023 Jan 17;12(2):195. doi: 10.3390/antibiotics12020195

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Biogenesis and regulation of the type VI secretion system (T6SS) in A. baumannii. The T6SS is a class of macromolecular secretion machines, which translocate proteins into a variety of recipient cells: (a) A single gene cluster carries 18 putative genes that are predicted to encode components of the T6SS. Among them, 12 core genes (tss) are coded on the chromosome of A. baumannii ATCC 17978. (b) The T6SS is composed of three main parts: a membrane complex (TssJ, TssL, and TssM), a cytoplasmic baseplate (TssK, TssF, TssG, TssE, VgrG, and PAAR), and a contractile tail tube/sheath complex (Hcp, TssB, TssC, and TssA). The expression of the T6SS is negatively regulated by the TetR-like proteins encoded on the large, conjugative plasmid pAB3 and proteins within the H-NS family.