Cumulative survival according to the VWF:Ag/ADAMTS13:AC in patients with liver cirrhosis in the post-ACLF group. The patients with LC in the post-ACLF group were categorized into two groups according to the ROC cutoff of the VWF:Ag/ADAMTS13:AC levels (low, ≤9; and high, >9). The cumulative survival was significantly lower in patients with LC in the post-ACLF group with high VWF:Ag/ADAMTS13:AC levels compared with those with low VWF:Ag/ADAMTS13:AC levels (HR, 10.72; 95% CI, 1.39–82.78; p < 0.05). ACLF, acute-on-chronic liver failure; ROC, receiver operating characteristic; LC, liver cirrhosis; ADAMTS13, a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs 13; ADAMTS13:AC, ADAMTS13 activity; VWF, von Willebrand factor; VWF:Ag, VWF antigen; VWF:Ag/ADAMTS13:AC, the ratio of VWF:Ag to ADAMTS13:AC; HR, hazard ratio; CI, confidence interval.