Table 6.

Summary of wound-healing properties of MH, TH, KH, and SH.

Type of Honey	Type of Study	Findings	References
MH	In vitro	MH eradicated and inhibited methicillin-resistant S. aureus (MRSA) from colonized wounds by interrupting cell division.	[215]
MH	In vitro	Combination MH with rifampicin was stopped the appearance of rifampicin-resistant S. aureus, which was rapidly lost in the presence of rifampicin alone.	[216]
TH	In vivo	The treatment groups were received TH (0.2 mL), there was a 14% and 73% reduction in wound size by day 9 and day 15 in the TH-treated wounds; however, this increased by 106% and 24% by day 12 and day 15, respectively.	[217]
TH	In vivo	The treatment groups were received TH (0.1 mL/cm2) dressing on the first burn wound, hydrofibre on the second wound, and hydrofibre silver on the last wound.Wound size was found to be markedly reduced in the TH-treated wounds on day 3, 9 and 15. The wounds showed a reduction in size of 12.86% by day 3 from the original 100 mm2 in the TH-treated wounds. They further decreased in size of 33.94% by day 9 post-burn. The wound healing process was observed for up to 21 days. On day 21, TH-treated wounds in P. aeruginosa inoculated group and A. baumannii inoculated groups healed completely. The remaining wounds in P. aeruginosa inoculated group and A. baumannii inoculated groups and all the wounds in K. pneumonia inoculated wounds did not healed completely.	[218]
TH	In vivo	The treatment groups were given TH 1.0 g/kg every morning until day seven post operatively, oral treatment with TH enhanced anastomotic wound healing by increasing the number of fibroblasts and decreasing inflammatory cells towards increased wound strength.	[219]
TH	Human	The treatment groups were received 3 mL of TH intraoperatively followed by 4 mL of oral TH three times daily for seven days, TH has positive effect in enhancing healing process in post tonsillectomy patient. It is easy to use topically, safe to consume orally and available at low cost locally. Overall it can be used as an excellent adjunct therapy for post-operative patients.	[220]
KH	In vivo	The treatment groups were given KH (1183 mg/kg) twice daily for 30 consecutive days by oral administration and on day 31, the rats were induced with absolute ethanol (5 mL/kg) via oral administration after being fasted for 24 h and were sacrificed 15 min after the induction. Pretreatment with KH significantly reduced (p < 0.05) both the total area of ulcer and the ulcer index compared to the positive control group. The percentage of ulcer inhibition in the KH pre-treated group was 65.56% compared with the positive control group. The treatment, KH, exhibited antiulcer properties against ethanol induced gastric ulcer.	[222]
KH	In vitro	KH reduced TGFβ-induced EMT in human primary keratinocytes, indicating its therapeutic potential in preventing keloid scar formation.	[221]
SH	In vivo	The treatment groups were received 1 to 2 mL of SH twice a day for one week and then once daily until the end of the study period (28 d). SH showed a beneficial effect of SH on second-intention healing of full thickness contaminated wounds and also wounds treated by SH healed as fast as those wounds treated by iodine.	[223]
SH	In vivo	The treatment groups were treated with 500 mg of SH (0, 7, 14 and 21 days), SH was found to possess higher healing rate of wounds induced either by thermal or chemical methods, In general, SH could be employed as topical wound healing agent and was also proved that SH could be used as natural wound healing agents besides commercial synthetic analogs.	[224]