Figure 5.

Structural context of LRP4 mutations. (A) Map of structural domains and mutations within the LRP4 protein sequence. Structural domains are coded by color as indicated. The residue numbering is based on accession number NCBI: NP_002325.2. The starting position of each structural domain is marked on the bottom and the ending position on the top. (B) Three-dimensional model of the LRP4 structure predicted by AlphaFold2 with structural domains in the same colors as in part A. Magnified views of the wild type and mutated amino acids and surrounding amino acids in stick representation are shown to the side to indicate the molecular environment. Possible polar interactions are shown as dashed lines. Oxygen atoms are shown in red, nitrogen in blue and sulfur atoms in yellow, while carbon atoms are colored according to the domain color. The intracellular domain has no predicted structure and is shown schematically as a box.