Figure 3.

The application of solvent casting/particulate leaching technique for a gradient OC tissue scaffold. Reproduced with permission from Ref. [128]. Copyright 2012, Wiley. (A) Schematic model of the structure and process of a highly porous polycaprolactone-based osteochondral composite scaffold produced by the solvent casting/particle leaching technique. (B) SEM micrograph of the double-layered scaffold, taken with the secondary electronic detector. (C,D) H&E and toluidine blue staining of double-layered monolithic osteochondral scaffolds after 9 weeks of implantation in immunodeficient mice (scale bar = 100 µm).