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. 2023 Feb 3;11(2):449. doi: 10.3390/biomedicines11020449

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic representation of the domain composition of titin and fragments used in the present study. (A) Domain composition of titin. Fibronectin domains are shown in white, Ig domains in purple and unique sequences in grey. Titin kinase (TK) is in orange. Titin sarcomeric regions and A-band super-repeats are annotated. The first domain of each zone is numbered. Segments studied in this work are underlined. The MIR segment and its constituents studied in this work are shown; (B) Amino acid sequence of I110 and its corresponding 9 synthetic peptides in this work (horizontal thin lines under the sequence).