[11C]PiB |
(11)C-labeled Pittsburgh Compound-B |
[11C]UCBJ |
(4R)-1-[(3-(11C)Methylpyridin-4-yl)methyl]-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one |
[18F] |
fluorine radioisotope |
[18F]FDG |
[18F]Fluorodeoxyglucose |
[18F]MNI-1126 |
18F analog of [11C]UCB-J PET radioligand |
[18F]SDM-16 |
(4R)-4-(3-fluoro-5-(fluoro-18F)phenyl)-1-((2-methyl-1H-imidazol-1-yl)methyl)pyrrolidin-2-one |
[18F]SDM-16 |
(4R)-4-(3-(18F)fluoranyl-5-fluorophenyl)-1-[(3-methylpyridin-4-yl)methyl]pyrrolidin-2-one (UIPAC name) |
[18F]SDM-8 |
(4R)-4-(3-(18F)fluoranyl-5-fluorophenyl)-1-[(3-methylpyridin-4-yl)methyl]pyrrolidin-2-one |
[18F]SynVesT-1 |
(4R)-4-(3-(18F)fluoranyl-5-fluorophenyl)-1-[(3-methylpyridin-4-yl)methyl]pyrrolidin-2-one |
[18F]UCB-H |
(4R)-1-((3-Fluoranyl-4-pyridyl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one |
99-CTF |
99-amino acid membrane bound C-terminal fragment |
99-CTF |
99-amino acid membrane-bound C-terminal fragment |
Aβ |
amyloid β |
AβF |
amyloid β fibril |
AβPF |
amyloid β protofibril |
AD |
Alzheimer’s disease |
ADHD |
attention deficit hyperactivity disorder |
aMCI |
amnestic mild cognitive impairment |
AMPA |
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid |
AMPAR |
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor |
APOE3 |
apolipoprotein E3 |
APOE4 |
apolipoprotein E4 |
APP |
amyloid-β precursor protein |
APP |
amyloid precursor protein |
APP669–711 |
amyloid-β precursor protein isoforms |
ATN |
(amyloidβ (A), phosphorylated tau (T) and neurodegeneration (N) markers) |
ATP |
adenosine triphosphate |
AβO(s) |
amyloid β oligomer(s) |
BDNF |
brain-derived neurotrophic factor |
BOLD |
blood oxygenation level-dependent |
bvFTD |
behavioural variant of frontotemporal dementia |
CA1 |
hippocampal subfield/region CA1 |
CaMKII |
Ca2+/calmodulin-dependent protein kinase II |
cdk5 |
cyclin-dependent kinase 5 |
CJD |
Creutzfeldt–Jakob disease |
CREB |
cAMP response element-binding protein |
CSF |
cerebrospinal fluid |
DAB1 |
DAB adaptor protein 1 |
DAB1-P |
phosphorylated DAB adaptor protein 1 |
DMN |
default mode network |
DNA |
deoxyribonucleic acid |
DTI |
diffusion tensor imaging |
EEG |
electroencephalogram |
EM |
electron microscopy |
EMG |
electromyography |
EphB2 |
ephrin type-B receptor 2 |
FAD |
familial Alzheimer’s disease |
FDG-PET |
fluorine-18 fluorodeoxyglucose PET imaging |
fMRI |
functional magnetic resonance imaging |
FYN |
proto-oncogene tyrosine-protein kinase Fyn |
GABA |
gamma-aminobutyric acid |
GABAB |
gamma-aminobutyric acid B receptor |
GAP-43 |
growth-associated protein 43 |
GluA2 |
ligand-gated ion channel glutamate receptor |
GluCEST |
glutamate chemical exchange saturation transfer |
GluN1 |
NMDA receptor subunit GluN1 |
GluN2B |
NMDA receptor subunit GluN2B |
GSK3β |
glycogen synthase kinase-3β |
HT |
histochemical techniques |
IDE |
insulin-degrading enzyme |
IFITM |
interferon-induced transmembrane protein |
IHC |
immunohistochemistry |
IHT |
immunohistochemical techniques |
LilrB2 |
leukocyte immunoglobulin-like receptor subfamily B member 2 |
LOAD |
late-onset form |
LTD |
long-term depression |
LTP |
long-term potentiation |
M1 microglia |
microglia releasing inflammatory mediators, promotes inflammation and neurotoxicity |
M2 microglia |
microglia releasing anti-inflammatory mediators, has an anti-inflammatory and neuroprotective effect. |
MCI |
mild cognitive impairment |
MEG |
magnetoencephalography |
mGluR5 |
metabotropic glutamate receptor 5 |
miRs |
microRNAs |
MMT |
memory manifold theory |
MMT |
memory manifold theory |
MRS |
MR spectroscopy |
MT |
mitochondria(l) |
MTT |
multiple trace theory |
NCAM |
neural cell adhesion molecule |
NFκB |
nuclear factor kappa-light-chain-enhancer of activated B cells |
NfL |
neurofilament light polypeptide/chain |
NFT |
neurofibrillary tangles |
NgR1 |
negative growth regulatory protein NGR1 |
NMDAR |
N-methyl-D-aspartate receptor, tetrameric protein with two GluN1 subunits and two GluN2 (A-D) subunits; a type of L-glutamate receptor |
NPT2 |
sodium-dependent phosphate transport protein 2A |
NS |
nucleation site |
P-tau |
phosphorylated tau protein |
PET |
positron emission tomography |
PET SV2 |
PET synaptic vesicle protein 2A tracer |
PI3K |
phosphoinositide 3-kinase |
PirB |
paired immunoglobulin-like receptor |
PKA |
protein kinase A |
PKB |
protein kinase B |
PMN |
parietal memory network |
PSD-95 |
postsynaptic density protein 95 (a postsynaptic scaffolding protein in excitatory neurons) |
PSD(s) |
postsynaptic density protein(s) |
R-fMRI |
resting state fMRI, evaluates intrinsic brain networks at rest by calculating correlations between brain regions |
Rab |
member of the Ras superfamily small G proteins |
RAGE |
receptor for advanced glycation end products, aka AGER |
ROS |
reactive oxygen species |
SCI |
subjective cognitive impairment |
SCTs |
standard consolidation theories |
SEM |
scanning electron microscopy |
SMC |
sensorimotor cortex |
SNAP-25 |
synaptosomal-associated protein 25 |
SPECT |
single-photon emission computerized tomography |
SV2(A) |
synaptic vesicle glycoprotein 2(A) |
T-tau |
total tau |
TEM |
transmission electron microscopy |
TNFα |
tumour necrosis factor α |
VaD |
vascular dementia |
VDAC1 |
voltage-dependent anion-selective channel 1 |