Figure 1.

Effects of repeated oxaliplatin administration on pica, body weight, and stomach content. (A,B) Group data showing the consumption of normal chow (A) and kaolin (B) for 24 h over 14 days following oxaliplatin administration. A significant decrease in normal chow consumption while a significant increase in kaolin consumption was observed in the oxaliplatin-treated group. (C) The percentage of body weight decreased over time, starting from day 3 up to day 14 in chronic oxaliplatin-treated mice. (D) Group data showing the full stomach, empty stomach, and stomach content weight at days 3, 7, and 14 following oxaliplatin injection. Data are presented as the mean ± SEM. The number of animals is shown in parentheses. •, *** p < 0.001, ■ p < 0.001, ♦, * p < 0.05.