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. 2023 Feb 1;13(2):276. doi: 10.3390/biom13020276

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of repeated oxaliplatin administration on the myenteric neurons and inhibitory motor neurons in whole mount preparations of the stomach. (A) Myenteric neurons labelled with the pan-neuronal marker PGP9.5 (red) and (C) inhibitory motor neurons labelled with the antibody for neuronal nitric oxide synthase (nNOS) (purple) in the gastric corpus at days 3, 7, and 14 following the injection of sterile water (sham) and oxaliplatin (oxal). Scale bar: 100 μm. (B,D) Group data showing the average number of PGP9.5-IR neurons and nNOS-IR neurons counted per a 0.25 mm² area in wholemount preparations of the gastric corpus of sham and oxal-treated mice. Data are presented as the mean ± SEM. The number of animals is shown in parentheses. *** p < 0.001; * p < 0.05.

Effects of repeated oxaliplatin administration on the myenteric neurons and inhibitory motor neurons in whole mount preparations of the stomach. (A) Myenteric neurons labelled with the pan-neuronal marker PGP9.5 (red) and (C) inhibitory motor neurons labelled with the antibody for neuronal nitric oxide synthase (nNOS) (purple) in the gastric corpus at days 3, 7, and 14 following the injection of sterile water (sham) and oxaliplatin (oxal). Scale bar: 100 μm. (B,D) Group data showing the average number of PGP9.5-IR neurons and nNOS-IR neurons counted per a 0.25 mm² area in wholemount preparations of the gastric corpus of sham and oxal-treated mice. Data are presented as the mean ± SEM. The number of animals is shown in parentheses. *** p < 0.001; * p < 0.05.