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. 2023 Feb 1;13(2):276. doi: 10.3390/biom13020276

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of chronic oxaliplatin treatment on cholinergic nerve activity. (A) A representative recording of blood pressure (BP) (pulsatile and mean), vagus nerve activity (VNA) (rectified) [arbitrary units (a.u.)], vagus nerve amplitude (VNamp), and vagus nerve frequency (VNf) in vehicle-treated and chronic oxaliplatin-treated rats. (B) Grouped data of basal VNf and VNamp in vehicle-treated and oxaliplatin-treated rats. Effects are shown as absolute (VNf (bpm, bursts per minute)) or arbitrary (VNA, VNamp) values. Data are presented as the mean ± SEM. The number of animals is shown in parentheses. * p < 0.05 compared to the vehicle-treated group.