Figure 1.

Single-cell atlas of AD and normal ascending aorta samples. (A) Schematic diagram of the sample processing and experimental workflow employed. (B) UMAP plot of the 79,544 cells profiled, including ten main cell types in nine samples. Below the graph are legends color-coded by the assigned cell type. (C) UMAP plots of the AD group (six samples) and normal group (three samples). (D) Bar plot depicting the proportions of the ten main cell types in the AD and normal groups. (E) Heatmap of the top ten DEGs for the ten main cell types. (F) Dot plot of selected marker genes for each cell type. The dot size represents the percentage of cells expressing each gene, while the dot color represents the level of expression. UMAP, uniform manifold approximation and projection; DEGs, differentially expressed genes.