Table 1.
Patient and tumor characteristics.
| Feature | Primary Tumors | Relapse | Overall |
|---|---|---|---|
| N. (%) * | N. (%) * | N. (%) * | |
| Total number | 58 | 11 | 69 |
| Age: median (range) | 66 (41–81) | 57 (45–78) | 64 (41–81) |
| Sex | |||
| Female | 22 (38) | 6 (55) | 28 (41) |
| Male | 36 (62) | 5 (45) | 41 (59) |
| Type of resection | |||
| Gross total resection | 15 (28) | 3 (43) | 18 (30) |
| Subtotal resection | 15 (28) | 1 (14) | 16 (27) |
| Partial resection | 23 (43) | 3 (43) | 26 (43) |
| N.A. | 5 (-) | 4 (-) | 9 (-) |
| Alive at the end of follow up | |||
| Yes | 4 (7) | 1 (9) | 5 (7) |
| No | 54 (93) | 10 (91) | 64 (93) |
| Histotype | |||
| Glioblastoma | 56 (97) | 10 (91) | 66 (96) |
| Gliosarcoma | 2 (3) | 1 (9) | 3 (4) |
| Hemisphere | |||
| Right | 32 (55) | 5 (46) | 37 (54) |
| Left | 26 (45) | 4 (36) | 30 (43) |
| Other ** | 0 (0) | 2 (18) | 2 (3) |
| Multifocal | |||
| No | 47 (81) | 9 (82) | 56 (81) |
| Yes | 11 (19) | 2 (18) | 13 (19) |
| IDH1 mutated | 0 (0) | 0 (0) | 0 (0) |
| MGMT promoter | |||
| Methylated | 21 (38) | 7 (78) | 28 (43) |
| Unmethylated | 35 (62) | 2 (22) | 37 (57) |
| N.A. | 4 (-) | 2 (-) | 4 (-) |
| Mib1: median (range) | 35% (4–80%) | 43% (10–60%) | 35% (4–80%) |
| P53 | |||
| Negative | 7 (12) | 4 (36) | 11 (16) |
| Intermediate | 40 (69) | 4 (36) | 44 (64) |
| Positive | 11 (19) | 3 (27) | 14 (20) |
| P53 | |||
| Wild type | 40 (69) | 4 (36) | 44 (64) |
| Mutated | 18 (31) | 7 (64) | 25 (36) |
| CD3 | |||
| Absent | 10 (17) | 2 (18) | 12 (17) |
| Mild | 37 (64) | 7 (64) | 44 (64) |
| Moderate/High | 11 (19) | 2 (18) | 13 (19) |
| CD3+ TILs count: median (range) | 8 (0–90) | 11 (1–57) | 9 (0–90) |
| PD-L1 | |||
| <1% | 33 (57) | 8 (73) | 41 (59) |
| ≥1% | 25 (43) | 3 (27) | 28 (41) |
N.A., not available. * Percentages are calculated within the columns of the table (Primary tumors, Relapse, Overall) and excluding the missing values. ** Other: one bilateral, one along the fourth ventricle.