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. 2023 Jan 28;12(2):196. doi: 10.3390/biology12020196

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Physiological decline of the “Remember” component of recognition memory during aging in control mice and neuroprotection by He2 primordium extract in supplemented mice. For each panel, control (C) animals are represented with red bars, dots, and histograms, while supplemented (P) mice are symbolized by green bars, dots, and histograms. Panel (A,B) describe OL test: discrimination index (DI) of the number (A) and time of approaches (B). Panel (C) is related to Y maze task (alternation triplets %). Panel (D) display Remember cognitive Frailty Index (FI): scatter plot showing integrated FIs for individual C and P mice (left upright); linear least-square regression of experimental points averaged data (left downright). On the right, separated tables report statistical data concerning age-related effect in C (upright) and P (downright) mice. Statistically significant data: p < 0.05 (£, #, *); p < 0.01 (££, ##, **); p < 0.001 (***).