Table 2.
In silico tools for designing aptamers.
| Tools | Features | Reference |
|---|---|---|
| Apta-loopEnc | Labels the candidates with high and low binding affinity. Predicts aptamer based on SVM | [101] |
| AptaSUITE | Framework analysis of data from HT-SELEX such as sequences and aptamer counts. | [102] |
| SMART-Aptamer | Predicts aptamers based on ranking of sequence abundance, stability of the secondary structure | [77] |
| RaptRanker | Predicts aptamer based on structure and frequency of sequence | [103] |
| PPAI (http://39.96.85.9/PPAI/, accessed on 30 December 2022) | Web server for prediction of aptamers and interaction between protein and aptamer | [104] |
| AptCompare | Meta-analysis platform for HT-SELEX | [105] |
| APTANI2 | GUI platform for aptamers based on frequency of sequence and stability of secondary structure | [106] |
| AptaNet | Predicts the affinity of aptamer-protein using a multi-layer perceptron as a classification model. | [107] |