Figure 4.

Female 5xFAD mice show age-dependent deficits in spatial reference memory in the probe trial. WT animals (a,d,g) and 3-month-old 5xFAD mice (b) showed a clear preference for the target quadrant during the probe trial. In contrast, 7- and 12-month-old 5xFAD mice demonstrated no clear preference for the target quadrant (e,h). Swimming speed did not vary between 5xFAD and WT mice (c,f,i). TQ = target quadrant, LQ = left quadrant, RQ = right quadrant, OQ = opposite quadrant. Data presented as mean ± S.E.M., n = 10–13. Quadrant preference: one-way repeated measures ANOVA followed by Bonferroni correction for multiple comparisons: * p < 0.05, ** p < 0.01, *** p < 0.001. Swimming speed: unpaired t-test.