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. 2023 Jan 21;11(2):305. doi: 10.3390/biomedicines11020305

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Renal expression of cathepsin B protein is attenuated by metformin treatment. (A) Western blot for cathepsin B protein expression in kidney cortex lysates from vehicle-treated or metformin-treated diabetic db/db mice maintained on an HSD. (B) Densitometric analysis of the immunoreactive band in panel A normalized to actin (C) Immunohistochemistry showing cathepsin B protein expression in the kidneys of hypertensive diabetic db/db mice treated with vehicle or metformin. N = 8. Data are plotted as mean ± SEM, *** represents a p-value < 0.001, and a.u. represents arbitrary units.