Table 1.
Clinical and physiologic parameters for 10 compounds studied with GABAA receptors in this study. Concentrations are given in μM. Data are mean ± standard error of the mean for 20–24 determinations. [CNS] denotes concentration of drug in the CNS. Imax(%) denotes maximum inhibition.
| Drug | Class | Use | [CNS] | GABA EC50 | Imax (%) | nH |
|---|---|---|---|---|---|---|
| EGCG | polyphenol | dietary supplement | 0.18 [35] | 31 ± 4 | 22 ± 8 | 1.1 |
| Chloroquine | aminoquinolone | antimalarial | 1.60 [36] | |||
| Clarithromycin | macrolide | antibiotic | 10 [37] | 20 ± 1 | 85 ± 8 | 1 |
| Erythromycin | macrolide | antibiotic | 0.68 [38] | |||
| Hydroxychloroquine | aminoquinolone | antimalarial | 50 [39] | 40 ± 8 | 29 ± 4 | 1.4 |
| Metronidazole | nitroimidazole | Antibiotic/protozoal | 7010 [40] | 50 ± 11 | 24 ± 9 | 0.8 |
| Minocycline | tetracycline | antibiotic | 1.1 [41] | |||
| Ofloxacin | quinolone | antibiotic | 5.6 [42] | 15 ± 4 | 61 ± 7 | 1 |
| pentylenetetrazole | azepine | stimulant/convulsant | 330 [43] | 10 ± 3 | 68 ± 5 | 1.3 |
| Rifampin | ansamycin | antibiotic | 3.60 [44] |