Table 2.
Characteristics of pregnant women (* VOC 2.5 + 1.4/years).
| Women Characteristics: | Pregancy N(%) | Global ESCORT HU Population |
|---|---|---|
|
Genotype SS |
89 (88%) | 84.0% |
| Sβ0 | 6 (5.9%) | 6.0% |
| Sβ+ | 4 (4.0%) | 7.0% |
| SC | 1 (0.1%) | 2.0% |
| ND | 1 (0.1%) | 0.2% |
| HU therapeutic indication | N | |
| VOC * | 66 | |
| ACS | 23 | |
| anemia | 6 | |
| Organopathy/vasculopathy | 7 | |
| Not reported | 2 | |
| Women characteristics: | Median [IQR1-3] | |
| Age of initiation of Siklos (years) | 28 [24–32] | |
| Siklos Dose at initiation (mg/kg) | 15 [13–19] | |
| Age of first menstrual period (years) | 15 [13–19] | |
| Age of first pregnancy (years) | 30 [26–33] | |
| Follow–up duration (month) | 52 [37–60] | |
| Number of visits | 10 [8–12] | |
| Age of pregnancy in the study (years) | 31 [26–35] | |
| Hb (g/dl) | 8.8 [7.9–9.5] | |
| HbF (%) | 8.8 [4.9–18.4] | |