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The response to the ribosome collision. Several sensor proteins detect the ribosome collision and induce different pathways. Hel2 (Znf598 in mammals) induces ribosome-associated quality control (RQC) and the no-go decay (NGD). The general control nonderepressible (GCN) complex induces an integrated stress response (ISR). ZAKα induces cell cycle arrest or apoptosis via the p38 or c-Jun pathway, respectively, which are called ribotoxic stress response (RSR).
