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Ribosome quality control triggering step. The ribosome collision is recognized by E3 ligase Hel2, which elongates the K63-linked poly-ubiquitination on the ribosomal protein uS10. The K63-linked polyubiquitination is recognized by the RQT complex via its components Cue3 and Rqt4, inducing the non-canonical ribosome dissociation for the leading stalling ribosome to resume translation.
