Figure 1.

Immune reactivity induced by HSP70. HSP70 response to stress may induce tolerogenic anti-inflammatory responses as well as immune reactivity. Intracellular HSP70 activation suppresses NLRP3 inflammasome activation. In addition, specific polypeptide sequences of HSP70 induce a tolerogenic responses characterized by IL-10 immunomodulatory secretion. In contrast, extracellular HSP70 induce immune reactivity that includes anti-HSP70 antibody formation. The chaperoning function of HSP70 include the protection and transfer of exogenous and endogenous antigenic peptides to the MHC I and II and the subsequent adaptive immune reactivity. Tolerogenic responses to intracellular HSP70 in dendritic cells and macrophages include reduction of TNFα and INFα and production of IL-10 by T cells. Suppression of T cell-induced inflammatory responses is independent of its effects on monocyte-derived immature dendritic cells [17].