Figure 1.

Clearance of Aβ by glial cells. (A) Microglia form a physical barrier to protect neurons. (B) Increasing the breakdown by microglial proteases could enhance the clearance of Aβ deposits. (C) The phagocytic activity of microglia could be enhanced by targeting receptors and signal pathways involved in this response. (D) Inflammation caused by microglia produce both pro-inflammatory and anti-inflammatory factors. (E) Microglia can secrete cytokines to activate astrocytes. (F) Microglia participate in amyloid-dependent synaptic dysfunction.