Table 3.
Clinico-pathological features of TC patients (n = 226) according to the areas of residence (Grosseto Province).
| Parameters | Amiata Mountain (n = 16) (%) |
Grosseto Zone (n = 120) (%) |
Albegna Hills (n = 21) (%) |
Orbetello Lacuna (n = 21) (%) |
Metal Hills District (n = 48) (%) |
p |
|---|---|---|---|---|---|---|
| Age at diagnosis (yrs) | 0.06 | |||||
| Mean ± SD | 49.6 ± 12.9 | 53 ± 13.7 | 47 ± 19.1 | 55.7 ± 10.8 | 47.7 ± 14.4 | |
| Range | 22–70 | 23–84 | 33–74 | 8–76 | 22–85 | |
| Median | 47 | 52 | 59.5 | 50.5 | 48 | |
| Sex | 0.6 | |||||
| Males | 4 (25) | 34 (28.3) | 6 (28.6) | 9 (42.8) | 17 (35.4) | |
| females | 12 (75) | 86 (71.7) | 15 (71.4) | 12 (57.2) | 31 (64.6) | |
| Histotypes: n (%) | 0.9 | |||||
| Papillary | 15 (93.7) | 109 (90.9) | 20 (95.2) | 20 (95.2) | 44 (91.8) | |
| Follicular | 1 (6.3) | 5 (4.1) | 0 | 1 (4.8) | 1 (2.0) | |
| Medullary | 0 | 4 (3.3) | 1 (4.8) | 0 | 2 (4.2) | |
| Anaplastic/Undifferentiated | 0 | 2 (1.7) | 0 | 0 | 1 (2.0) | |
| Variants of PTC n (%) | 0.3 | |||||
| Classical | 1/13 (7.7) | 29/94 (30.8) | 4/16 (25) | 3/16 (18.8) | 11/37 (29.7) | |
| Follicular | 6/13 (46.1) | 34/94 (36.2) | 3/16 (18.8) | 8/16 (50) | 12/37 (32.4) | |
| Tall cell | 3/13 (23.1) | 18/94 (19.1) | 7/16 (43.8) | 2/16 (12.4) | 5/37 (13.6) | |
| Solid | 2/13 (15.4) | 12/94 (12.8) | 1/16 (6.2) | 3/16 (18.8) | 7/37 (18.9) | |
| Diffuse Sclerosing | 1/13 (7.7) | 1/94 (1.1) | 1/16 (6.2) | 0 | 2/37 (5.4) | |
| Diameter of tumor: (cm) | 0.7 | |||||
| Mean ± SD | 1.8 ± 1.3 | 1.7 ± 1.3 | 1.5 ± 0.8 | 1.4 ± 0.8 | 1.7 ± 1.4 | |
| Range | 0.2–5 | 0.1–6 | 0.2–3 | 0.2–3.5 | 0.1–8 | |
| Median | 1.5 | 1.4 | 1.5 | 1.5 | 1.3 | |
| Tumor extension: n (%) * | 0.5 | |||||
| T1a | 5 (31.2) | 36 (30) | 5 (23.8) | 5 (23.8) | 14 (29.2) | |
| T1b | 2 (12.5) | 38 (31.7) | 9 (42.9) | 11 (52.4) | 15 (31.2) | |
| T2 | 4 (25) | 14 (11.7) | 5 (23.8) | 3 (14.3) | 7 (14.6) | |
| T3 | 5 (31.3) | 31 (25.8) | 2 (9.5) | 2 (9.5) | 11 (22.9) | |
| T4 | 0 | 1 (0.8) | 0 | 0 | 1 (2.1) | |
| Lymph-node metastases: n (%) | 0.2 | |||||
| Yes | 3 (18.7) | 14 (11.7) | 6 (28.6) | 4 (19) | 7 (14.6) | |
| No | 13 (81.3) | 106 (88.3) | 15 (71.4) | 17 (80.9) | 41 (85.4) | |
| Distant metastases: n (%) | 0.8 | |||||
| Yes | 0 | 2 (1.7) | 0 | 0 | 1 (2.1) | |
| No | 16 (100) | 118 (98.3) | 21 (100) | 21 (100) | 47 (97.9) | |
| Bilaterality: n (%) | 0.3 | |||||
| Yes | 7 (43.7) | 57 (47.5) | 9 (42.8) | 13 (61.9) | 17 (35.4) | |
| No | 9 (56.3) | 63 (52.5) | 12 (57.2) | 8 (38.1) | 31 (64.6) | |
| Multicentricity: n (%) | 0.3 | |||||
| Yes | 7 (43.7) | 56 (46.7 | 9 (42.8) | 14 (66.7) | 19 (39.6) | |
| No | 9 (56.3) | 64 (53.3) | 12 (57.2) | 7 (33.3) | 29 (60.4) |
* refer to TNM 8th edition.