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. 2023 Jan 19;11(2):269. doi: 10.3390/biomedicines11020269

Figure 1.

Figure 1

Structure and activation of CNG channels. (A) Membrane topology of CNG channel subunits: 1–6, transmembrane segment 1–6; C, carboxy-terminus; CNBD, cyclic nucleotide-binding domain; N, amino-terminus. (B) Model of the CNG channel complex embedded in the plasma membrane based on the human rod CNGA1/CNGB1 channel structure (PDB 7RHH). (C) Top and bottom views of the heterotetrameric human rod CNGA1/CNGB1 channel complex. (D) Subunit composition of the CNG channels from rods and cones. Structures in this figure were generated with the RSCB PDB 3D View tool (www.rcsb.org/3d-view/ accessed on 19 Dec 2022) based on PDB 7RHH.