The Sensitivity of Tau Tracers for the Discrimination of Alzheimer’s Disease Patients and Healthy Controls by PET

. 2023 Feb 3;13(2):290. doi: 10.3390/biom13020290

Compound, Term, Acronym	Figure	Names, Synonyms
Astemizole	Figure 4b	hismanal; histaminos; paralergin; loaridal; retolen; astemison; 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl] benzimidazol-2-amine; CAS-RN: 68844-77-9
AV-1451		T807; 7-(6-fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole; CAS RN: 1415379-56-4
[¹⁸F]AV1451	Figure 5a	[¹⁸F]flortaucipir; [¹⁸F]T807; [¹⁸F]LY 3191748; [¹⁸F]AV-1451; 7-(6-[¹⁸F]fluoro-pyridin-3-yl)-5H-pyrido[4,3-b]indole; CAS RN: 1522051-90-6
BBB		blood brain barrier
BF-158	Figure 2a	N-methyl-4-(quinolin-2-yl)aniline; CAS RN: 682763-67-3
[¹¹C]BF-158	Figure 2e	N-[¹¹C]methyl-4-(quinolin-2-yl)aniline
BF-168	Figure 2c	(E)-4-(2-(6-(2-fluoroethoxy)benzo[d]oxazol-2-yl)vinyl)-N-methylaniline; CAS RN: 634911-47-0
BF-170	Figure 2b	2-(4-aminophenyl)quinoline
[¹¹C]BF-227	Figure 2g	(E)-5-(2-(6-(2-fluoroethoxy)benzo[d]oxazol-2-yl)vinyl)-N-methyl-N-[¹¹C]methyl-thiazol-2-amine
BF-242	Figure 2d	THK-523; 4-[6-(2-fluoroethoxy)-2-quinolinyl]aniline; CAS RN: 1573029-17-0
[¹⁸F]BF-242	Figure 2f	[¹⁸F]THK-523; 4-[6-(2-[¹⁸F]fluoroethoxy)-2-quinolinyl]aniline
BIP		benzimidazopyridine
[¹²⁵I]BIP-NMe₂	Figure 9a	7-[¹²⁵I]iodo-N,N-dimethylbenzo[[4,5]]imidazo[1,2-a]pyridin-3-amine
[¹⁸F]Br-BIPF	Figure 9d	7-bromo-N-(2-([¹⁸F]fluoroethyl)-N-methylbenzo[[4,5]]imidazo[1,2-a]pyridin-3-amine
[¹⁸F]Cl-BIPF	Figure 9e	7-chloro-N-(2-[¹⁸F]fluoroethyl)-N-methylbenzo[[4,5]]imidazo[1,2-a]pyridin-3-amine
[¹⁸F]IBIPF1	Figure 9b	N-(2-[¹⁸F]fluoroethyl)-7-iodo-N-methylbenzo[[4,5]]imidazo[1,2-a]pyridin-3-amine
[¹⁸F]IBIPF2	Figure 9c	N-(2-[¹⁸F]fluoroethyl)-7-iodobenzo[[4,5]]imidazo[1,2-a]pyridin-3-amine
[¹⁸F]Me-BIPF	Figure 9f	N-(2-[¹⁸F]fluoroethyl)-N,7-dimethylbenzo[[4,5]]imidazo[1,2-a]pyridin-3-amine
[¹⁸F]OMe-BIPF	Figure 9g	N-(2-([¹⁸F]fluoroethyl)-7-methoxy-N-methylbenzo[[4,5]]imidazo[1,2-a]pyridin-3-amine
DDNP	Figure 1b	1,1-dicyano-2-[6-(dimethylamino)naphthalene-2-yl]propene; 2-[1-[1-(dimethylamino)naphthalen-2-yl]ethylidene]propanedinitrile; CAS RN: 178385-38-1
FDDNP		FDDNP; DMFEAN 2-[1-[6-[2-fluoroethyl(methyl)amino]naphthalen-2-yl]ethylidene]propanedinitrile CAS RN: 590365-47-2
[¹⁸F]FDDNP	Figure 1a	Fddnp F-18; [¹⁸F]UNII-3J4JP3286H 2-[1-[6-[2-[¹⁸F]fluoroethyl(methyl)amino]naphthalen-2-yl]ethylidene] propanedinitrile; CAS RN: 259738-99-3
FENE	Figure 1d	1-(6-[(2-fluoroethyl)(methyl)amino]naphthalen-2-yl)ethanone CAS RN: 1260894-66-3
[¹⁸F]FENE	Figure 1e	1-(6-[(2-[¹⁸F]fluoroethyl)(methyl)amino]naphthalen-2-yl)ethanone
flortaucipir		T807; 7-(6-fluoropyridin-3-yl)-5H-pyrido[4,3-b]indole; CAS RN: 1415379-56-4
[¹⁸F]flortaucipir	Figure 5a	[¹⁸F]T807; [¹⁸F]LY 3191748; [¹⁸F]AV-1451; 7-(6-[¹⁸F]fluoro-pyridin-3-yl)-5H-pyrido[4,3-b]indole; CAS RN: 1522051-90-6
[¹⁸F]GTP1	Figure 7b	Genetech Tau Probe 1
[¹⁸F]JNJ-64326067	Figure 8d	[¹⁸F]JNJ067; N-(4-[¹⁸F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine N-[4-[¹⁸F]fluoro-5-methyl-2-pyridinyl]-6-isoquinolinamine, CAS RN: 2173357-42-9
[¹⁸F]JNJ-64349311	Figure 8c	[¹⁸F]JNJ311; ¹⁸F-JNJ 311; 6-[¹⁸F]fluoro-N-(2-methyl-4-pyridinyl)-1,5-naphthyridin-2-amine; CAS RN: 2121497-78-5
[¹⁸F]JNJ (Co. No. 2)	Figure 8b	6-[¹⁸F]fluoro-N-(3-methyl-4-pyridinyl)-1,5-naphthyridin-2-amineCAS RN: 2121497-79-6; Moechars, D.W.E. et al. AU Pat. 2017216212
[¹⁸F]JNJ (Co. Nr. 3)	Figure 8a	6-[¹⁸F]fluoro-N-4-pyridinyl-1,5-naphthyridin-2-amine CAS RN: 2121497-80-9, Moechars, D.W.E. et al. AU Pat. 2017216212
Lansoprazole	Figure 4a	prevacid; bamalite; monolitum; ogastro; agopton; 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole CAS RN: 103577-45-3
MK-6240		6-fluoro-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine CAS RN: 1841078-87-2
[¹⁸F]MK-6240	Figure 7a	[¹⁸F]MNI-946; 6-[¹⁸F]fluoro-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine
NML	Figure 4c	N-Methyl-lansoprazole; 1-methyl-2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]benzimidazole
[¹¹C]NML	Figure 4d	[¹¹C]-N-Methyl-lansoprazole; 1-[¹¹C]methyl-2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]benzimidazole
[¹⁸F]NML	Figure 4e	[¹⁸F]-N-Methyl-lansoprazole; 2-(((4-(2,2-difluoro-2-[¹⁸F]fluoro-ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1-methyl-1H-benzo[d]imidazole
PI-2620		2-(2-[¹⁸F]fluoro-pyridin-4-yl)-9H-pyrrolo[2,3-b:4,5-c’]dipyridine
[¹⁸F]PI-2620	Figure 7f	[¹⁸F]MNI-960; 11-(2-[¹⁸F]fluoranylpyridin-4-yl)-4,8,10-triazatricyclo[7.4.0.0^2,7]trideca-1(9),2(7), 3,5,10,12-hexaene; 2-(2-([¹⁸F]fluoro-4-pyridinyl)-9H-pyrrolo(2,3-b:4,5-c’)dipyridine; CAS RN: 2173353-61-0
PBB		pyridinyl-butadienyl-benzothiazole
PBB3		2-[(1E,3E)-4-[6-(methylamino)pyridin-3-yl]buta-1,3-dienyl]-1,3-benzothiazol-6-ol CAS RN: 1565796-97-5
[¹¹C]PBB3	Figure 6a	2-[(1E,3E)-4-[6-[¹¹C]methylamino)pyridin-3-yl]buta-1,3-dienyl]-1,3-benzothiazol-6-ol; CAS RN: 1565797-40-1
[¹⁸F]PBB3	Figure 6b	2-((1E,3E)-4-(2-[¹⁸F]fluoro)-6-(methylamino)pyridin-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-ol
PIB		6-OH-BTA-1; Pittsburgh Compound B 2-[4-(methylamino)phenyl]-6-benzothiazolol CAS RN: 566169-93-5
[¹¹C]PIB	Figure 1f	[N-methyl-¹¹C]-6-OH-BTA-1, CAS RN: 566170-04-5
PM-PBB3		APN-1607; 1-fluoro-3-((2-((1E,3E)-4-(6-(methylamino)pyridin-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-yl)oxy)propan-2-ol
[¹⁸F]PM-PBB3	Figure 6c	[¹⁸F]APN-1607; [¹⁸F]MNI-958; 1-[¹⁸F]fluoro-3-((2-((1E,3E)-4-(6-(methylamino)pyridine-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-yl)oxy)propan-2-ol, CAS RN 1565797-57-0
RO-6924963		Ro963; 2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-7-amine
[¹¹C]RO-6924963	Figure 7e	[¹¹C]R0963; 2-(4-([¹¹C]methoxy)phenyl)imidazo[1,2-a]pyridin-7-amine
RO-6931643		Ro643; N-methyl-2-(m-tolyl)imidazo[1,2-a]pyrimidin-7-amine
[¹¹C]RO-6931643	Figure 7c	[¹¹C]Ro643; N-[¹¹C]methyl-2-(m-tolyl)imidazo[1,2-a]pyrimidin-7-amine
RO-6958948		RO-948; 2-(6-fluoro-pyridin-3-yl)-9H-pyrrolo[2,3-b:4,5-c’]dipyridine
[¹⁸F]RO-6958948	Figure 7d	[¹⁸F]Ro948; 2-(6-([¹⁸F]fluoro-)pyridin-3-yl)-9H-pyrrolo[2,3-b:4,5-c’]dipyridine
[¹⁸F]S16	Figure 3i	(S)-1-(4-(6-(dimethylamino)quinoxalin-2-yl)phenoxy)-3-fluoropropan-2-ol
T807		flortaucipir; LY 3191748; AV-1451
[¹⁸F]T807	Figure 5a	[¹⁸F]flortaucipir; [¹⁸F]LY 3191748; [¹⁸F]AV-1451
T808		AV-680; 2-[4-(2-Fluoroethyl)-1-piperidinyl]pyrimido[1,2-a]benzimidazole CAS RN; 1320211-61-7
[¹⁸F]T808	Figure 5b	[¹⁸F]AV-680; 2-[4-(2-[¹⁸F]Fluoroethyl)-1-piperidinyl]pyrimido[1,2-a]benzimidazole
Tauvid	Figure 5a	¹⁸F-AV-1451, ¹⁸F-T807, Flortaucipir F-18
THK-523	Figure 2d	4-[6-(2-fluoroethoxy)-2-quinolinyl]aniline 2-(4-Aminophenyl)-6-(2-(fluoroethoxy))quinoline; CAS RN: 1573029-17-0
[¹⁸F]THK-523	Figure 2f	4-[6-(2-[¹⁸F]fluoroethoxy)-2-quinolinyl]aniline 2-(4-Aminophenyl)-6-(2-([¹⁸F]fluoroethoxy))quinoline
THK-951		2-[(N-Methyl-4-amino)phenyl]quinolin-7-ol
[¹¹C]THK-951	Figure 3a	2-(4-([¹¹C]methyl)-amino)phenyl)quinolin-7-ol
THK-5105		1-((2-(4-(dimethylamino)phenyl)quinolin-6-yl)oxy)-3-fluoropropan-2-ol
[¹⁸F]THK-5105	Figure 3b	1-((2-(4-(dimethylamino)phenyl)quinolin-6-yl)oxy)-3-[¹⁸F]fluoropropan-2-ol
[¹⁸F]THK-5116	Figure 3c	1-((2-(4-aminophenyl)quinolin-6-yl)oxy)-3-[¹⁸F]fluoropropan-2-ol
THK-5117		1-fluoro-3-[2-[4-(methylamino)phenyl]quinolin-6-yl]oxypropan-2-ol CAS RN: 1374107-54-6
[¹⁸F]THK-5117	Figure 3d	1-[¹⁸F]fluoro-3-[2-[4-(methylamino)phenyl]quinolin-6-yl]oxypropan-2-ol
THK-5317		6-((3-fluoro-2-hydroxy)propoxy)-2-(4-methylaminophenyl)quinoline
[¹⁸F]THK-5317	Figure 3f	6-((3-[¹⁸F]fluoro-2-hydroxy)propoxy)-2-(4-methylaminophenyl)quinoline
THK-5351		GE-216; (2R)-1-fluoro-3-[2-[6-(methylamino)pyridin-3-yl]quinolin-6-yl]oxypropan-2-ol CAS RN: 2101218-44-2
[¹¹C]THK-5351	Figure 3h	(2R)-1-fluoro-3-[2-[6-([¹¹C]methylamino)pyridin-3-yl]quinolin-6-yl]oxypropan-2-ol
[¹⁸F]THK-5351	Figure 3g	[¹⁸F]GE-216; (2R)-1-[¹⁸F]fluoro-3-[2-[6-(methylamino)pyridin-3-yl]quinolin-6-yl]oxypropan-2-ol