Table 4.

CSF biomarkers concentration.

Patients n = 242	MS n = 134	SID n = 28	CVD n = 10	NID n = 70
INF-γ (pg/mL)	9.9 (43.6) 0.0 [0.0–5.2]	29.3 (87.4) 0.9 [0.0–9.9]	12.9 (23.7) 1.2 [0.0–16.1]	4.7 (10.8) 0.0 [0.0–4.6]
IL6 (pg/mL)	23.9 (64.7) 0.0 [0.0–6.4]	26.9 (83.1) 5.5 [1.2–10.0]	20.9 (59.1) 0.0 [0.0–5.7]	18.2 (57.4) 0.0 [0.0–4.6]
OPN (ng/mL)	189.1 (274.9) 95.3 [37.9–170.7]	112.2 (221.2) 53.4 [30.9–108.4	66.1 (52.9) 43.2 [32.8–67.6]	89.5 (134.8) 51.5 [28.8–86.6]
CXCL13 (pg/mL)	260.7 (250.3) 207.8 [71.2–397.6]	411.2 (802.3) 129.4 [0.0–452.4]	295.6 (359.9) 157.7 [62.5–301.9]	260.0 (251.9) 220.9 [33.4–418.5]
NF-L (ng/mL)	1.4 (2.1) 0.8 [0.4–1.5]	4.3 (9.6) 0.6 [0.4–3.9]	1.0 (1.7) 0.5 [0.3–0.6]	0.6 (0.6) 0.3 [0.3–0.5]
CHI3L1 (ng/mL)	32.9 (63.3) 10.9 [5.7–29.8]	33.4 (48.9) 27.5 [6.7–38.1]	39.2 (69.9) 21.5 [7.5–28.8]	38.9 (59.5) 27.1 [6.8–33.8]

All values reported as mean (standard deviation) in the first row and median [Q1–Q3] in the second row. IFN-γ, interferon gamma; NF-L, neurofilaments light chain; CHI3L1, chitinase-3-like-1; OPN, osteopontin.