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Schematic drawing of tryptophan metabolism through the kynurenine pathway. Enzymes: tryptophan 2,3-dioxygenase (TDO), indole 2,3-dioxygenase (IDO), kynurenine aminotransferase (KAT), kynurenine 3-monooxygenase (KMO), kynureninase (KYNU), and quinolinate phosphoribosyl transferase (QPRT). Cofactors: vitamin B6 (pyridoxal 5′-phosphate, PLP) and vitamin B2.
