Table 4.
Determinants of plasma B6 vitamers and kynurenine concentrations with multiple linear regression 1.
| Independent Variables | Pyridoxal 5-Phosphate, nmol/L | Pyridoxal, nmol/L | 4-Pyridoxic Acid, nmol/L | ||||||
|---|---|---|---|---|---|---|---|---|---|
| B | 95%CI for B | p Value | B | 95%CI for B | p Value | B | 95%CI for B | p Value | |
| Omnivore vs. vegetarian diet | 22.2 | 1.9, 42.4 | 0.03 | 11.9 | 7.1, 16.6 | <0.001 | 16.5 | 8.7, 24.3 | <0.001 |
| Use of micronutrient supplements 2 | 32.8 | 11.8, 53.9 | 0.002 | 8.2 | 3.2, 13.1 | 0.001 | 17.1 | 9.0, 25.3 | <0.001 |
| Serum C-Reactive Protein 3 | −3.6 | −7.8, −0.5 | 0.09 | −0.3 | −1.3, 13.0 | 0.51 | −0 | −2, 1 | 0.61 |
| Plasma cotinine 3 | −0 | −0, 0 | 0.71 | 0 | −0, 0 | 0.82 | 0 | −0, 0 | 0.65 |
| Independent Variables | Kynurenine, µmol/L | 3-Hydroxykynurenine, nmol/L | Kynurenic Acid, nmol/L | ||||||
| B | 95%CI for B | p value | B | 95%CI for B | p value | B | 95%CI for B | p value | |
| Omnivore vs. vegetarian diet | −0.2 | −0.3, −0.1 | 0.003 | −10 | −15, −4 | <0.001 | −12 | −19, −6 | <0.001 |
| Use of micronutrient supplements 2 | 0.1 | −0.1, 0.2 | 0.34 | 0.6 | −5, 6 | 0.84 | 4 | −3, 11 | 0.25 |
| Serum C-Reactive Protein 3 | −0 | −0, 0.2 | 0.75 | 1 | 0, 2 | 0.04 | −3 | −4, −1 | <0.001 |
| Plasma cotinine 3 | 0 | 0, 0 | 0.08 | −0 | −0, 0 | 0.09 | −0 | −0, 0 | 0.30 |
| Independent Variables | Anthranilic Acid, nmol/L | 3-Hydroxyanthranilic Acid, nmol/L | Xanthurenic Acid, nmol/L | ||||||
| B | 95%CI for B | p value | B | 95%CI for B | p value | B | 95%CI for B | p value | |
| Omnivore vs. vegetarian diet | −2 | −4, 0.1 | 0.06 | −17 | −24, −9 | <0.001 | −8 | −12, −4 | <0.001 |
| Use of micronutrient supplements 2 | 0.5 | −1.5, 2.5 | 0.62 | 6 | −2, 14 | 0.14 | 2 | −2, 6 | 0.36 |
| Serum C-Reactive Protein 3 | −0.1 | −0.5, 0.3 | 0.52 | −0 | −2, 1 | 0.86 | 0 | −1, 1 | 0.68 |
| Plasma cotinine 3 | −0 | −0, 0 | 0.62 | −0 | −0, 0 | 0.35 | −0 | −0, 0 | 0.09 |
| Independent Variables | Picolinic Acid, nmol/L | Quinolinic Acid, nmol/L | Nicotinamide, nmol/L | ||||||
| B | 95%CI for B | p value | B | 95%CI for B | p value | B | 95%CI for B | p value | |
| Omnivore vs. vegetarian diet | −15 | −25, −6 | 0.002 | −38 | −104, 27 | 0.25 | −65 | −118, −11 | 0.02 |
| Use of micronutrient supplements 2 | 4 | −6, 14 | 0.38 | 44 | −24, 113 | 0.20 | 5 | −50, 60 | 0.86 |
| Serum C-Reactive Protein 3 | −2 | −4, −0.5 | 0.01 | 16 | 3, 30 | 0.02 | −3 | −14, 8 | 0.62 |
| Plasma cotinine 3 | −0 | −0, 0 | 0.65 | −0.1 | −0.1, 0 | 0.27 | −0 | −0.1, 0 | 0.30 |
1 The regression models contain age, body mass index, and use of alcohol (units per week) as independent variables, in addition to the parameters listed in the table. 2 Use of micronutrient supplements: non-regular use vs. regular use (≥3 days per week). 3 Serum CRP and plasma cotinine as continuous variables.