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. 2023 Jan 23;13(2):219. doi: 10.3390/biom13020219

Figure 5.

Figure 5

Activation of TRKB signaling in ∆K280 TauRD-DsRed SH-SY5Y cells. p-TRKB (Y516 and Y817), TRKB, p-AKT (S473), AKT, p-CaMKII (T286), CaMKII, p-ERK (T202/Y204), ERK, p-RSK (S380), RSK, p-CREB (S133), CREB, BDNF (pro- and mature), BCL2, BAX and CASP3 levels analysed by immunoblotting using GAPDH as a loading control (n = 3). To normalize, the protein expression level in uninduced cells was set at 100%. p values: comparisons between induced vs. uninduced cells (#: p < 0.05, ##: p < 0.01, ###: p < 0.001), or compound-treated vs. untreated cells (*: p < 0.05, **: p < 0.01, ***: p < 0.001) (one-way ANOVA with a post hoc Tukey test).