Figure 4.

Open-field behavior during monthly testing between 2- and 11-month. (A,B) Distance traveled in centimeters during 5 min observation period. There was no overall difference between sexes, however the 3xTg-AD mice moved significantly less than age-matched controls (p < 0.01). (C,D) Percent of time spent in the center of the open field during 5 min observation. The 3xTg-AD animals spent less time in the center of the open field than the control group (p = 0.026). Data are shown as the mean ± SEM. The individual raw data points are represented as triangles. * p < 0.05, ** p < 0.01 vs. Control. The blues represent male (normal blue: control group, pale blue: intervention group), and the reds represent females ( normal red: control, pale red: intervention).