Table 4.
Statistical data (results of mixed ANOVA) of open-field test (Experiment 2) and corresponding body weight in male and female, control and 3xTg-AD mice. The corresponding data are presented on Figure 4. Repeated measurements were conducted from 2 to 11 month of age. Significant main effects are highlighted in red, while blue colour represents marginally significant difference.
| Degree of Freedom | F | p | |
|---|---|---|---|
| Distance travelled (cm) | |||
| Genotype | 1, 23 | 53.972 | 0.000 |
| Sex | 1, 23 | 1.017 | 0.324 |
| Genotype × Sex | 1, 23 | 3.567 | 0.072 |
| Time | 9, 207 | 20.267 | 0.000 |
| Genotype × Time | 9, 207 | 7.736 | 0.000 |
| Sex × Time | 9, 207 | 0.451 | 0.905 |
| Genotype × Sex × Time | 9, 207 | 2.822 | 0.004 |
| Time spent in centrum (%) | |||
| Genotype | 1, 23 | 5.662 | 0.026 |
| Sex | 1, 23 | 7.561 | 0.011 |
| Genotype × Sex | 1, 23 | 4.317 | 0.049 |
| Time | 9, 207 | 13.458 | 0.000 |
| Genotype × Time | 9, 207 | 1.508 | 0.147 |
| Sex × Time | 9, 207 | 0.410 | 0.186 |
| Genotype × Sex × Time | 9, 207 | 1.382 | 0.198 |
| Body weight (g) | |||
| Genotype | 1,26 | 1.554 | 0.224 |
| Sex | 1,26 | 57.509 | 0.000 |
| Genotype × Sex | 1,26 | 27.872 | 0.000 |
| Time | 9234 | 120.606 | 0.000 |
| Genotype × Time | 9234 | 0.694 | 0.714 |
| Sex × Time | 9234 | 1.429 | 0.176 |
| Genotype × Sex × Time | 9234 | 5.782 | 0.000 |