Figure 1.

The role of pericytes in leukocyte transmigration across the endothelial barrier. Stimulated pericytes induce the expression and release of various factors, attracting and facilitating trafficking of leukocytes across vessel walls (black arrows). In particular, neutrophils navigate through the venular walls with CXCL1 and CXCL2 chemokines, produced by ECs/PC and neutrophils, respectively, and EC junctions-enriched expression of CXCL2 receptor ACKR1 (atypical chemokine receptor 1) (magenta arrows).