Table 4.
Major studies evaluating the effects of phosphodiesterase-4 (PDE-4) inhibitors on obesity in patients with polycystic ovary syndrome.
| Reference | PDE-4 Inhibitor | n | Follow-Up (Weeks) |
Baseline Body Mass Index (kg/m2) | Lifestyle Intervention | Metformin Treatment | Main Results |
|---|---|---|---|---|---|---|---|
| [88] | Roflumilast 500 μg/day | 31 | 12 | 36.4 | No | Comparator arm | Roflumilast/metformin reduced body weight more than metformin |
| [89] | Roflumilast 500 μg/day | 41 | 12 | 38.6 | No | Comparator arm | Similar reduction in body weight compared with liraglutide and greater than with metformin |