Table 1.
Clinicopathologic characteristics of patients undergoing neoadjuvant therapy followed by curative intent resection of localized soft tissue sarcoma.
| Variable | Multiplex IHC (N = 19) |
NanoString (N = 32) |
ImmunoPrism (N = 26) |
|---|---|---|---|
| No. (%) | No. (%) | No. (%) | |
| Age* | 52.8 | 48.5 | 48.5 |
| (25.3–76.7) | (23.7–76.7) | (23.7–76.7) | |
| Sex | |||
| Male | 12 (63) | 19 (59) | 17 (65) |
| Female | 7 (37) | 13 (41) | 9 (35) |
| Location | |||
| Extremity | 17 (90) | 26 (81) | 21 (81) |
| Central | 1 (5) | 3 (9) | 3 (12) |
| Retroperitoneal | 1 (5) | 3 (9) | 2 (8) |
| Tumor Size | |||
| ≤5 cm | 2 (11) | 6 (19) | 4 (15) |
| >5 cm | 17 (89) | 26 (81) | 22 (85) |
| Grade (FNCLCC System) | |||
| 1 | 1 (5) | 5 (16) | 4 (15) |
| 2 | 8 (42) | 13 (41) | 10 (39) |
| 3 | 9 (47) | 13 (41) | 11 (42) |
| Unknown | 1 (5) | 1 (3) | 1 (4) |
| Histologic Type | |||
| Undifferentiated pleomorphic sarcoma | 12 (63) | 14 (44) | 12 (46) |
| Synovial Sarcoma | 2 (11) | 3 (9) | 2 (8) |
| Ewing Sarcoma | - | 3 (9) | 2 (8) |
| Leiomyosarcoma | 2 (11) | 2 (6) | 2 (8) |
| Myxoid/Round Cell Liposarcoma | 3 (16) | 3 (9) | 3 (12) |
| Other† | - | 7 (22) | 5 (19) |
| Preoperative Chemotherapy | |||
| Yes | 15 (79) | 21 (66) | 18 (69) |
| No | 4 (21) | 11 (34) | 8 (31) |
FNCLCC: French Federation of Comprehensive Cancer Centers.
*
Age at diagnosis is displayed as median (min-max) in years.
†
Other histologies: 2 myxofibrosarcomas; 1 each of fibroblastic-myofibroblastic sarcoma, sclerosing epithelioid fibrosarcoma, solitary fibrous tumor, sarcoma with epithelioid features suggestive of MPNST, and low grade fibromyxoid sarcoma