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Enhanced tumor volumes (red) and functional tumor volumes (blue) in a 61-year-old patient with TNBC with a pathologic complete response at surgery. (a,d) Baseline. (b,e) After 2 cycles of neoadjuvant systemic therapy (NAST). (c,f) After 4 cycles of NAST. No segmentation was performed after 4 cycles since there was no residual tumor enhancement at that time. Functional tumor volume (bottom row) is the subset of enhanced tumor volume (top row), satisfying the PE and SER thresholds.
