. 2023 Feb 6;15(4):1025. doi: 10.3390/cancers15041025

Table 2.

Longest tumor dimension (LD), tumor volume (TV), and enhanced tumor volume (ETV) measurements by neoadjuvant systemic therapy response status.

Measurement	AUC [95% CI]	p-Value	Mean ± SD		Best Cutoff for ROC Curve
Measurement	AUC [95% CI]	p-Value	Non-pCR (N = 51)	pCR (N = 49)	Best Cutoff for ROC Curve
LD at 1 min, cm
BL	0.58 [0.47–0.70]	0.148	3.58 ± 1.54	3.24 ± 1.75	4.35
C2	0.72 [0.61–0.82]	<0.001	2.92 ± 1.45	2.06 ± 1.34	1.45
C4	0.76 [0.66–0.85]	<0.001	2.34 ± 1.41	1.74 ± 1.57	0.95
%C2/BL	0.75 [0.66–0.85]	<0.001	−16.94 ± 21.88	−36.12 ± 22.10	−19.38
%C4/BL	0.77 [0.68–0.86]	<0.001	−32.58 ± 27.78	−67.88 ± 34.78	−49.58
LD at 7 min, cm
BL	0.58 [0.47–0.70]	0.156	3.71 ± 1.51	3.39 ± 1.77	4.20
C2	0.71 [0.61–0.81]	<0.001	3.11 ± 1.49	2.25 ± 1.33	2.45
C4	0.76 [0.66–0.85]	<0.001	2.71 ± 1.72	1.39 ± 1.52	1.35
%C2/BL	0.76 [0.67–0.86]	<0.001	−14.84 ± 21.46	−31.24 ± 18.37	−15.39
%C4/BL	0.75 [0.65–0.84]	<0.001	−23.91 ± 47.09	−58.85 ± 35.06	−49.14
TV at 1 min, cm³
BL	0.61 [0.50–0.72]	0.061	24.22 ± 32.09	15.14 ± 27.26	22.65
C2	0.73 [0.63–0.83]	<0.001	12.80 ± 18.53	4.72 ± 8.02	4.42
C4	0.77 [0.68–0.86]	<0.001	7.55 ± 15.63	2.20 ± 5.47	0.32
%C2/BL	0.77 [0.67–0.86]	<0.001	−39.21 ± 39.23	−69.29 ± 26.64	−67.46
%C4/BL	0.77 [0.68–0.87]	<0.001	−62.41 ± 39.34	−86.94 ± 23.91	−99.40
TV at 7 min, cm³
BL	0.60 [0.49–0.71]	0.080	25.23 ± 32.61	16.62 ± 28.24	30.37
C2	0.73 [0.63–0.83]	<0.001	13.65 ± 19.84	5.53 ± 8.98	4.21
C4	0.77 [0.67–0.86]	<0.001	8.84 ± 17.45	2.69 ± 6.35	0.77
%C2/BL	0.75 [0.65–0.85]	<0.001	−38.51 ± 35.95	−66.41 ± 22.50	−56.42
%C4/BL	0.76 [0.67–0.85]	<0.001	−59.77 ± 40.96	−85.73 ± 19.25	−72.83
ETV at 1 min, cm³
BL	0.62 [0.51–0.73]	0.038	12.98 ± 13.89	10.14 ± 23.64	13.55
C2	0.80 [0.70–0.89]	<0.001	5.30 ± 6.07	2.09 ± 4.19	1.25
C4	0.82 [0.73–0.90]	<0.001	2.75 ± 5.58	1.07 ± 3.82	0.54
%C2/BL	0.76 [0.66–0.86]	<0.001	−45.60 ± 31.91	−72.06 ± 26.00	−69.14
%C4/BL	0.73 [0.62–0.83]	<0.001	−71.15 ± 27.17	−86.06 ± 21.81	−87.58
ETV at 2.5 min, cm³
BL	0.62 [0.51–0.73]	0.038	14.70 ± 15.44	11.20 ± 26.82	17.18
C2	0.78 [0.68–0.87]	<0.001	6.26 ± 6.84	2.54 ± 4.59	1.99
C4	0.79 [0.70–0.88]	<0.001	3.40 ± 6.73	1.13 ± 3.80	0.39
%C2/BL	0.74 [0.64–0.84]	<0.001	−43.25 ± 35.44	−69.60 ± 27.30	−63.88
%C4/BL	0.72 [0.62–0.82]	<0.001	−69.12 ± 31.05	−87.36 ± 18.42	−88.28

AUC, area under the receiver operating characteristic curve; SD, standard deviation; pCR, pathologic complete response; BL, baseline; C2, after 2 cycles of neoadjuvant systemic therapy (NAST); C4, after 4 cycles of NAST; %C2/BL, change between baseline and C2; %C4/BL, change between baseline and C4.