%	Percentage
°C	Degrees Celsius
<	Less than
>	Greater than
145-2C11	Mouse ati-CD3 antibody
2-DG	2-Deoxy-D-glucose; glucose analog
3D	three dimensional
4-1BB	Costimulatory Receptor
α	alpha
β	beta
δ	delta
ε	epsilon
γ	gamma
ζ	zeta
αβ	alpha-beta TCR chains
γδ	gamma-delta TCR chains
δε	delta-epsilon CD3 subunit
γε	gamma-epsilon CD3 subunit
ζζ	zeta-zeta CD3 subunit
ADCC	Antibody-dependent cellular cytotoxicity
AP-1	Activator protein; key transcription factor involved in T cell activation
APC	Antigen Presenting Cell
aPD-1	Anti- PD-1 antibody; immune checkpoint blockade
aPDL-1	Anti- PD-L1 antibody; immune checkpoint blockade
AX-024	T cell inhibitor
BCMA	B-cell maturation antigen; Tumor associated antigen in hematological
BCR	B Cell Receptor, expressed on B cells
BiTE	Bispecific T Cell Engager; CD3Ab-TAA bispecific antibody
BRS	Basic-Rich Stretch; signaling motif in CD3/TCR subunits
Ca2+	Calcium ions; released upon T cell activation
CAR T cells	Chimeric Antigen Receptor T cells; Modified T Cell based cancer immunotherapy
CD123	Tumor associated antigen in hematological cancers
CD19	Tumor associated antigen in hematological cancers
CD20	Tumor associated antigen in hematological cancers
CD27	Tumor associated antigen in hematological cancers
CD28	Costimulatory Receptor
CD3	Cd3 signalling subunit of the CD3-TCR complex on T cells
CD3+	CD3 expressing
CD33	Tumor associated antigen in hematological cancers
CD38	Tumor associated antigen in hematological cancers
CD39	Enzyme that converts ATP to ADP; ATP/adenosine pathway
CD3ɛ−/−	CD3 knock out
CD3-TCR	CD3-T Cell Receptor complex expressed on T Cells, composed of 1:1:1:1 ratio TCRαβ:CD3γε:CD3δε:CD3ζζ subunits
CD3δ	CD3 delta
CD3ε	CD3 epsilon
CD3γ	CD3 gamma
CD3ζ	CD3 zeta
CD3γε	Gamma-Epsilon heterodimeric subunit of the TCR/CD3 receptor complex
CD3δε	Delta-Epsilon heterodimeric subunit of the TCR/CD3 receptor complex
CD3ζζ	Zeta-Zeta homodimeric subunit of the TCR/CD3 receptor complex
CD4+	CD4+ Helper T cell
CD40	Costimulatory Receptor
CD43	Protein tyrosine phosphatase that favors dephosphrylation of ITAMs
CD45	Protein tyrosine phosphatase that favors dephosphrylation of ITAMs
CD47	“Don’t eat me” signal expressed on tumor cells to prevent phagocytosis by macrophages
CD69	Early T cell activation marker
CD73	Enzyme that converts AMP to Adenosine; ATP/adenosine pathway
CD79αβ	Signalling subunit of the B Cell Receptor
CD8+	CD8+ Cytotoxic T cell
CDC	complement-dependent cytotoxicity
CDRs	Complementarity-determining regions on T cells; involved in pMHC binding
CEA	Carcinoembryonic antigen; a type of tumor associated antigen
CNS	Central Nervous System
CRISPR/Cas9	clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9; genomic engineering technique
CTLA-4	Negative regulator of the immune response; Exhaustion marker on T cells
DAG	Diacylglycerol kinase involved in T cell activation signaling
DGKα	Diacylglycerol Kinase Alpha
DLL3	Delta-like ligand 3; tumor associated antigen in neuroendocrine tumors
DNA	Deoxyribonucleic acid; Double stranded nucleic acid composed of the bases A, T, G and C
EAE	Experimental autoimmune encephalomyelitis
EGFRviii	Epidermal growth factor receptor variant III; tumor associated antigen in glioblastoma
EM	Electron Microscopy
EpCAM	Epithelial Cell Adhesion Molecule; tumor associated antigen
Fab	Antigen-binding fragment on antibody
Fc	Fragment crystallizable; Antigen non-binding fragment on antibody
FDA	U.S. Food and Drug Administration
FYN	src superfamily protein tyrosine kinases involved in ITAM phosphorylation
G4.18	Anti-CD3 antibody
GMP	Good manufacturing practice; production quality regulations for clinical products and therapies
gp100	Cognate peptide for PMEL T cells
HCV	Hepatitis C Virus
HER-2	Human epidermal growth factor receptor 2; tumor associated antigen in breast cancers
HIF1-α	Hypoxia-inducible factor 1-alpha; key transcription factor that drives hypoxia
HLA	Human leukocyte antigens
IBD	inflammatory bowel disease
ICB	Immune Checkpoint Blocakde
ICOS	Inducible T-cell COStimulator; Costimulatory Receptor
IFN-γ	Interferon Gamma; T cell activation cytokine
IL-10	Interleukin-10; anti-inflammatory cytokine
ImmTAC	Immune mobilizing monoclonal T-cell receptors against cancer
IP3	Inositol trisphosphate
ITAM	Immunoreceptor tyrosine-based activation motif; involved in activation of T cells
lL-2	Iinterleukin-2; T cell activation cytokine
LCK	src superfamily protein tyrosine kinases involved in ITAM phosphorylation
LIGS	Ligand-Guided Selection; a type of modified SELEX
mAb	Monoclonal antibody
MHC	Major Histocompatibility Complex; proteins involved in self-discrimination
miRNAs	microRNA; non-coding ssRNA molecule
MS	Multiple Sclerosis
MUC16	Mucin 16; tumor associated antigen
NASH	nonalcoholic steatohepatitis
NCK	Non-catalytic region of tyrosine kinase; second messenger in T cell signalling
NFAT	Nuclear factor of activated T-cells; key transcription factor involved in T cell activation
NF-κB	Nuclear Factor kappa-light-chain-enhancer of activated B cells; key transcription factor involved in T cell activation
nM	Nanomolar
NOD	Nucleotide oligomerization domain
NSCLC	Non-small-cell lung carcinoma
OKT3	Human Anti-CD3 antibody
OX-40	Costimulatory Receptor
PD-1	Programmed cell death protein 1; negative regulator of the immune response; Exhaustion marker on T cells
PDL-1	Programmed death-ligand 1; negative regulator of the immune response
PLC	Phospholipase C; second messenger in T cell activation signaling
PLP139–151 EAE	PLP139–151 peptide-induced Experimental autoimmune encephalomyelitis
pMHC	Peptide-Major Histocompatibility Complex; cognate ligand for the T cell Receptor
PRS	Proline-Rich Stretch; signaling motif in CD3/TCR subunits
PSMA	Prostate-Specific Membrane Antigen; tumor associated antigen in prostate cancer
pSMAC	Peripheral supramolecular activation complex; macromolecular structure of TCRs in activated T cells
PTPN2	Protein tyrosine phosphatase non-receptor type 2
PTPN22	Protein tyrosine phosphatase non-receptor type 22
RAG1/2	Recombination-activating gene 1/2
Ras	Rat sarcoma virus protein; small GTPase
RNA	Riboxynucleic Acid; single stranded oligonucleotide containing the bases Adenine, Guanine, Uracil and Cytosine.
scFvs	Single Chain Variable Fragment; fusion protein of heavy and variable chains of the antigen binding arm of an antibody
SCID	Severe combined immunodeficiency
SELEX	Systematic Evolution of Ligands by Exponential Evolution; the process through which aptamers are identified
SH.3	Src Homology 3 (SH3) domains; signaling motif present in protein tyrosine kinases
SHP1	Src homology region 2 domain-containing phosphatase-1
siRNAs	Small interfering RNA; non-coding RNA used to silence genes
SJL/J	Swiss Jim Lambert EAE mice
Src	src superfamily protein tyrosine kinases involved in ITAM phosphorylation
SSTR2	Somatostatin receptor 2; Tumor associated antigen in pancreatic cancer
TCR	T Cell Receptor; expressed on T cells
TCR-CD3	CD3-T Cell Receptor complex expressed on T Cells, composed of 1:1:1:1 ratio TCRαβ:CD3γε:CD3δε:CD3ζζ subunits
TCR α-β	alpha beta T Cell
TCR-scFv	fusion protein containing a TCR and a single chain variable fragment
TCRα	alpha chain of the TCR
TCRβ	beta chain of the TCR