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. 2023 Feb 7;12(4):533. doi: 10.3390/cells12040533

Figure 3.

Figure 3

Intermittent fasting in Apoe-/- mice improves glucose tolerance. (A–D) Intraperitoneal glucose tolerance test (IPGTT). At 12 weeks of intervention, ad libitum (AL) and intermittent fasting (IF) Apoe-/- mice were fasted for 16 h and received an intraperitoneal injection of glucose (1 g/kg). Glycemia was measured at the indicated times (left panel), and the respective area under the curve (AUC) was calculated (right panel) for CD-fed males (A), CD-fed females (B), HFCD-fed males (C), and HFCD-fed females (D). (E–H) Intraperitoneal insulin tolerance test (ITT). Two weeks after IPGTT, the same mice were fasted for 5 h and received an intraperitoneal injection of insulin (0.5 U/kg). Glycemia was measured at the indicated times (left panel), and the respective area under the curve (AUC) was calculated (right panel) for CD-fed males (E), CD-fed females (F), HFCD-fed males (G), and HFCD-fed females (H). Values are expressed as means ± SEM (n = 5–9 per group); ns: not significant; * p < 0.05, ** p < 0.01, *** p < 0.001.