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. 2023 Feb 14;15(4):1219. doi: 10.3390/cancers15041219

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Molecular domains of the human CREBBP/EP300. CREBBP and EP300 have similar domain components and also share high sequence homology. Each domain is represented by a different color, and the number represents the location of the domain. NRID: nuclear receptor interaction domain; NLS: nuclear location signal; TAZ1: transcriptional-adaptor zinc-finger domain 1; KIX: kinase-inducible domain of CREB-interacting domain; CRD1: cell cycle regulatory domain 1; RING: really interesting new gene; PHD: plant homeodomain; HAT: histone acetyltransferase; ZZ: ZZ-type zinc finger; TAZ2: transcriptional-adaptor zinc-finger domain 2; IBiD: interferon-binding domain.