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. 2023 Feb 4;13(2):266. doi: 10.3390/brainsci13020266

Figure 4.

Figure 4

Ranitidine decreases preference-based anxiety-like behaviors in cysteamine HCl-treated mice during the light–dark box test (LDBT). The images represent video tracking in LDBT of an animal from the (A) control (CTR), (B) cysteamine HCl (CYS), (C) ranitidine (RNT), and (D) cysteamine HCl + ranitidine (CYS + RNT)-treated groups. The area outlined with blue represents the dark compartment, and the red color denotes the light compartment. The bar graph data indicates the time spent in (E) the dark and (F) the light compartments by mice in the control and treatment groups (* p-value ≤ 0.05 and *** p-value ≤ 0.001).