Figure 2.

Vascular normalization to restore the anti-tumor immune response in PDAC. Vascular normalization is expected to reverse the immunosuppressive tumor microenvironment, thus enabling response to immune checkpoint inhibitors (ICIs). In addition, the effect of hypoxia on increased tumor mutational burden (TMB) and genomic instability could potentially increase the production of neoantigens. The uptake of such foreign antigens and their presentation to T cells could then enable tumor-cell killing.