Table 1.

Other evidence of TB drivers.

TB Driver	Mechanism	Cancer Type	Year	Reference
COL4A1/COL13A1	Activation of intracellular AKT pathway leads to an E/N-cadherin switch	Urothelial carcinoma of bladder	2017	[31]
SerpinE1 (known as plasminogen activator inhibitor type 1)	Regulation of the plasminogen activator system	HNSCC	2019	[32]
c-MET	Upregulation of MET transcription	CRC	2016	[30]
Tenascin-C	Tenascin-C induces cancer cell EMT-like change	CRC	2018	[117]
SREBP1	Upregulation of MMP7expression and NF-κB pathway activation	CRC	2019	[118]
Increased tumor stroma Percentage and LDH-5	Decrease CD3+ lymphocyte stromal density	CRC	2019	[119]
Thymosin β4/β10	Modulation of cytoskeleton organization	CRC	2021	[120]