Table 6.
Univariate Analysis | |||||
Variable | HR | Confidence Interval | p Value | ||
Sex | M | 1.481 | 0.822 | 2.667 | 0.191 |
Histology | Leiomyosarcoma | 0.633 | 0.306 | 1.309 | 0.218 |
Age | 75–80 | 0.641 | 0.322 | 1.280 | 0.208 |
Age | ≥80 | 0.710 | 0.356 | 1.416 | 0.331 |
Location metastasis | Lung | 0.761 | 0.387 | 1.496 | 0.428 |
Location of primary tumour | Retroperitoneum | 1.687 | 0.852 | 3.341 | 0.134 |
Location of primary tumour | Other | 2.086 | 1.017 | 4.275 | 0.045 |
PS at metastatic disease | ≥2 | 2.754 | 1.526 | 4.971 | <0.001 |
Comorbidity grade according to CIRS | 3–4 | 1.043 | 0.502 | 2.171 | 0.91 |
Onco-MPI | High-risk | 4.743 | 1.150 | 19.56 | 0.03 |
First line chemotherapy | Yes | 0.193 | 0.106 | 0.354 | <0.001 |
Multivariate Analysis | |||||
Variable | HR | Confidence Interval | p Value | ||
Sex | Male | 1.4579 | 0.666 | 3.188 | 0.3450 |
Histology | Leiomyosarcoma | 0.5210 | 0.211 | 1.287 | 0.1574 |
Age | ≥80 | 0.3968 | 0.174 | 0.906 | 0.0283 |
Age | 75–80 | 0.5406 | 0.249 | 1.175 | 0.1203 |
Location of metastasis | Lung | 0.5860 | 0.268 | 1.280 | 0.1802 |
Location of primary tumour | Extremities/trunk | 2.0642 | 0.952 | 4.478 | 0.0666 |
Location of primary tumour | Other | 2.2186 | 0.959 | 5.129 | 0.0624 |
PS at metastatic disease | ≥2 | 2.0196 | 0.889 | 4.586 | 0.093 |
Comorbidity grade according to CIRS | 3–4 | 0.8535 | 0.366 | 1.989 | 0.7136 |
First line chemotherapy | YES | 0.2405 | 0.113 | 0.512 | 0.0002 |
Onco-MPI | High-risk | 5.5682 | 1.251 | 24.793 | 0.0242 |
Legend: CGA = Comprehensive geriatric assessment; CIRS = Cumulative illness rating scale ECOG = Eastern cooperative oncology group; PS = Performance status.