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Association of miRNAs with metabolism and gemcitabine resistance. Mainly, transporter and deoxycytidine kinase (dCK) are associated with the activation of gemcitabine. Conversely, cytidine deaminase (CDA) and ribonucleotide reductase (RR) are associated with the inactivation of gemcitabine. These transporters and enzymes are controlled by miRNAs, which results in gemcitabine resistance in pancreatic cancer.
